Linaclotide
keywords
- Linaclotide Base
- rega paling terjangkau
- CAS # 851199-59-2
Details cepet
- ProName: Linaclotide
- CasNo: 851199-59-2
- Formula molekul: C59H79N15O21S6
- Katon: bubuk putih
- Aplikasi: digunakake kanggo Ngruwat constipation
- DeliveryTime: kintunan pituduh
- Paket: miturut syarat customer kang
- Port: Shenzhen
- ProductionCapacity: 1 Kilogram / Wulan
- Purity: 98%
- Storage: 2 ~ 8 ℃. dilindhungi saka cahya
- Transportasi: udhara
- LimitNum: 1 Gram
kaunggulan
Rincian
Product: Linaclotide
Sinonim: Linaclotide Katandhan
CAS No.: 851199-59-2
Formula Molekuler: C59H79N15O21S6
Molekuler Bobot: 1526,8
Katon: Putih wêdakakêna
Purity:> 98%
urutan: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-ASN -Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH
Linaclotide punika tiron, patbelas peptida asam amino lan agonis saka usus jinis guanylate cyclase C (GC-C), kang structurally pranala menyang peptida kulawarga guanylin, karo secretagogue, analgesik lan aktivitas laxative. Senadyan administrasi lisan, linaclotide nemplek lan ngaktivasi reseptor GC-C dumunung ing lumahing luminal saka epitelium usus. Mundhak konsentrasi njero siklik guanosine monophosphate (cGMP), kang asalé saka guanosine trifosfat (GTP). cGMP ngaktivasi cystic fibrosis transmémbran conductance pengatur (CFTR) lan stimulates ing metune saka klorit lan bicarbonate menyang lumen usus. Iki dipun promosiaken sodium ekskresi menyang lumen lan asil tambah metune adi usus. Iki wekasanipun accelerates transit GI isi usus, mbenakake gerakan bagean paling njero lan relieves constipation. Tambah tingkat cGMP ekstraselular uga nandur pengaruh antinociceptive, liwat ing mekanisme durung ora sacara kebak ngandharaken, sing uga ndherek modulasi saka nociceptors ditemokaké ing serat pain afferent colonic. Linaclotide wis minimally digunakke saka ngambakake GI.
