Linaclotide
Mawu osakira
- Linaclotide Base
- mtengo kwambiri angakwanitse
- CAS # 851199-59-2
Tsatanetsatane Quick
- ProName: Linaclotide
- CasNo: 851199-59-2
- Maselo chilinganizo: C59H79N15O21S6
- Maonekedwe: ufa woyera
- Ntchito: ntchito kuchiritsa kudzimbidwa
- DeliveryTime: kutumiza mwamsanga
- Phukusi: malingana ndi zofuna za makasitomala a
- Port: Shenzhen
- ProductionCapacity: 1 kilogalamu / Mwezi
- Chiyero: 98%
- Yosungirako: 2 ~ 8 ℃. kutetezedwa ku kuwala
- Mayendedwe: ndi mpweya
- LimitNum: 1 galamu
Kudalirika
tsatanetsatane
Mankhwala: Linaclotide
lofanana: Linaclotide nthochi
CAS No.: 851199-59-2
maselo chilinganizo: C59H79N15O21S6
maselo Kulemera kwake: 1526,8
Maonekedwe: White ufa
Oyera:> 98%
akuyambira: NH2-Cys-Cys-Glu-Bakuman-Cys-Cys-Asn -Pro-Ala-Cys-Thr-Gly-Cys-Bakuman-HA
Linaclotide ndi kupanga, fortini kwa amino asidi peputayidi ndi agonist wa matumbo guanylate cyclase mtundu C (GC-C), chimene chiri amapanga ofanana kwa guanylin peputayidi banja, ndi secretagogue, analgesic ndi ntchito mankhwala ofewetsa tuvi tolimba. Pa makonzedwe m'kamwa, linaclotide chimango ndi imayendetsa GC-C zolandilira ili pa luminal padziko epithelium matumbo. Izi kumaonjezera ndende ya okhudza maselo ambiri ozungulira guanosine monophosphate (cGMP), amene anachokera ku guanosine triphosphate (GTP). cGMP imayendetsa ndi enaake fibrosis transmembrane conductance yang'anira (CFTR) ndipo kumapangitsa munthu katulutsidwe wa mankhwala enaake ndi bicarbonate mu lumen wa matumbo. Zimenezi zimathandiza ndi sodium excretion mu lumen ndi zotsatira kuchuluka matumbo katulutsidwe madzimadzi. Izi pamapeto pake Iyamba GI polumikizira ya nkhani matumbo, bwino matumbo kuyenda ndi relieves kudzimbidwa. Kuchuluka extracellular cGMP milingo amathanso khama zimakhudzanso antinociceptive, kudzera ngati limagwirira koma osati kwathunthu elucidated, zokhudzana kusinthasintha mawu a nociceptors pa colonic ulusi afferent ululu. Linaclotide ndi asang'ambe odzipereka kwa mundawo GI.
