Linaclotide
keywords
- Linaclotide Base
- mafi araha farashin
- CAS # 851199-59-2
Cikakken Bayani
- ProName: Linaclotide
- CasNo: 851199-59-2
- Kwayoyin Formula: C59H79N15O21S6
- Bayyanar: fararen foda
- Application: amfani ga magance maƙarƙashiya
- DeliveryTime: m kaya
- Kunshin: bisa ga abokin ciniki ta bukatun
- Port: Shenzhen
- ProductionCapacity: 1 kilogram / Watan
- Tsarki: 98%
- Storage: 2 ~ 8 ℃. kare su daga haske
- Transport: da iska
- LimitNum: 1 gram
magabaci
details
Product: Linaclotide
dangantawa: Linaclotide acetate
CAS No.: 851199-59-2
kwayoyin Formula: C59H79N15O21S6
kwayoyin Weight: 1526,8
Bayyanar: White foda
Tsarki:> 98%
jerin: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn -Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH
Linaclotide ne a roba, zuriya goma sha huɗu amino acid peptide da agonist na hanji guanylate cyclase irin C (GC-C), wanda shi ne fasali mai alaka da guanylin peptide iyali, tare da secretagogue, analgesic da laxative ayyukan. Bayan baka gwamnati, linaclotide ta ɗaure su da activates GC-C rabe located a kan luminal surface na hanji epithelium. Wannan qara maida hankali kwayuka cyclic guanosine monophosphate (cGMP), wanda aka samu daga guanosine triphosphate (GTP). cGMP activates da cystic fibrosis transmembrane conductance kayyadewa (CFTR) da kuma stimulates mugunya chloride da bicarbonate cikin hanji lumen. Wannan inganta sodium tukar tumbi cikin lumen da sakamakon a ƙara hanji ruwa mugunya. Wannan kyakkyawan accelerates GI sufuri da na hanji abinda ke ciki, da inganta hanji motsi da kuma sauqaqa maƙarƙashiya. Karuwan extracellular cGMP matakan iya exert wani antinociceptive sakamako, ta hanyar wani kamar yadda na duk da haka ba su cikakken daki-daki inji, cewa zai iya shafar daidaitowa na nociceptors samu a colonic afferent zafi zaruruwa. Linaclotide aka minimally tunawa daga GI fili.