Linaclotide
keywords
- Linaclotide Base
- qiimaha ugu jaban
- CAS # 851199-59-2
Details Quick
- ProName: Linaclotide
- CasNo: 851199-59-2
- Formula kelli: C59H79N15O21S6
- Imaanshaha: budada cad
- Codsiga: isticmaalo Daaweynta calool
- DeliveryTime: prompt shixnad
- Xirmo: waafaqsan shuruudaha macaamiisha ee
- Port: Shenzhen
- ProductionCapacity: 1 kiilo / Month
- Khayroon daahirnimo: 98%
- Kaydinta: 2 ~ 8 ℃. laga ilaaliyo iftiin
- Gaadiidka: by hawada
- LimitNum: 1 Gram
Fadilmo
Faahfaahin
Product: Linaclotide
Erayo Linaclotide copolymer
CAS No.: 851199-59-2
Formula kelli: C59H79N15O21S6
kelli Miisaanka: 1526,8
Imaansho: budada White
xagiisayna:> 98%
soo hormari: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn lacagihii Canshuuraha ee Ala-Cys-Thr-Gly-Cys-Tyr-OH
Linaclotide waa dardaro, iyo afar iyo toban peptide amino acid iyo agonist of xiidmaha nooca cyclase guanylate C (GC-C), taas oo ah qaab la xiriira qoyska guanylin peptide ah, la secretagogue, xanuunka iyo hawlaha caloosha jilcisa. Marka maamulka afka, linaclotide xidhana iyo shidaa receptors GC-C yaal dusha luminal of epithelium caloosha ku. Tani waxay kordhisaa-fiirsashada ee intracellular monophosphate guanosine xilliile (cGMP), kaas oo ka soo jeeda triphosphate guanosine (GTP). cGMP shidaa jaangooyaha ku fibrosis transmembrane fibrosis conductance (CFTR) iyo wuxuu kobciyaa dheecaan ah ee chloride iyo bicarbonate gelin Lumen xiidmaha. Tani waxay kor u Digo sodium galay Lumen iyo natiijooyinka ee kor u kacay dheecaan dheecaan xiidmaha. Tani waxay ugu dambeyntii dedejisaa transit GI ku jira xiidmaha, hagaajinaysaa saxaro iyo yareeyaa calool. La kordhiyo heerarka extracellular cGMP sidoo kale isticmaali laga yaabaa in saamayn antinociceptive, iyada oo ah sidii qaab aan weli si buuxda u elucidated, waxaa laga yaabaa in ku lug isbedbeddelka of nociceptors helay on fiiloyin afferent xanuun colonic. Linaclotide waa yar nuugo ka soo mareenka GI ka.
