Linaclotide
uputatala
- Linaclotide Base
- sili ona tau taugofie
- CAS # 851199-59-2
auiliiliga vave
- ProName: Linaclotide
- CasNo: 851199-59-2
- Fua Faatatau Molecular: C59H79N15O21S6
- Foliga Vaaia: efuefu paʻepaʻe
- Talosaga: faaaoga mo maopo manava masuasua
- DeliveryTime: uta vave
- Afifi: e tusa ai ma manaoga o le tagata e faaaogāina auaunaga
- Port: Shenzhen
- ProductionCapacity: 1 Kilogram / Masina
- Mama Atoatoa i Tulaga: 98%
- Teuina: 2 ~ 8 ℃. puipuia mai le malamalama
- Felauaiga: e ala i le ea
- LimitNum: 1 polokalama
faʻamanuiaga
auiliiliga
Oloa: Linaclotide
upu uiga tutusa: Linaclotide Acetate
CAS Nu: 851199-59-2
Fua Faatatau Molecular: C59H79N15O21S6
Weight Molecular: 1526,8
Foliga Vaaia: efuefu White
Mama:> 98%
Faasologa: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn -Pro-Ala-Cys-Thr-Gly-Cys-Tyr-Oi
Linaclotide o se gaosi, sefulufa amino acid peptide ma agonist o intestinal guanylate cyclase ituaiga C (GC-C), o structurally e fesootai i le aiga peptide guanylin, ma secretagogue, analgesic ma gaoioiga laxative. I le pulega tuufofoga, linaclotide e noatia ai ma activates GC-C receptors tu i le luminal luga o le epithelium intestinal. O lenei faateleina ai le faasalaga o monophosphate guanosine cyclic intracellular (cGMP), lea o loo maua mai i guanosine triphosphate (GTP). activates cGMP le Pule Faatonu conductance transmembrane cystic fibrosis (CFTR) ma uunaʻia le secretion o chloride ma bicarbonate i le lumen intestinal. uunaia excretion sodium lenei i le lumen ma taunuuga i faateleina secretion suāvai intestinal. O lenei iu faatelevaveina uia GI o le anotusi intestinal, faaleleia gaoioiga bowel ma relieves manava masuasua. mafai foi ona faateleina o le tulaga cGMP extracellular tuuina atu se aafiaga antinociceptive, e ala i se e pei o ae le atoatoa elucidated auala, e ono aafia modulation o nociceptors maua i alava colonic tiga afferent. Linaclotide ua minimally mitiia mai le tamaitusi GI.
