Linaclotide
Amagama angukhiye
- Linaclotide Base
- intengo kakhulu okungabizi
- CAS # 851199-59-2
Yekuchumana Quick
- ProName: Linaclotide
- CasNo: 851199-59-2
- Formula Yamamolekhula: C59H79N15O21S6
- Ukubukeka: powder emhlophe
- Isicelo: esetshenziselwa Ukwelapha ukuqunjelwa
- DeliveryTime: mpahla ngokushesha
- Iphakethe: ngokuvumelana nezimfuneko yekhasimende
- Port: Shenzhen
- ProductionCapacity: 1 Kilogram / Inyanga
- Uhlanzekile: 98%
- Isigcini: 2 ~ 8 ℃. bavikelekile ukukhanya
- Izinto zokuhamba: ngendiza
- LimitNum: 1 Gram
Ukuphakama
Yekuchumana
Umkhiqizo: Linaclotide
Emagama lafanako: Linaclotide acetate
CAS Cha: 851199-59-2
Formula Yamamolekhula: C59H79N15O21S6
Yamamolekhula Isisindo: 1526,8
Ukubukeka: White powder
Uhlanzekile:> 98%
Ukulandelana: NH2-Cys-Cys-Glu-Ezobuchwepheshe-Cys-Cys-ASN -Pro-Ala-Cys-thr-Gly-Cys-Ezobuchwepheshe-OH
Linaclotide kuyinto zokwenziwa, nane acid acid peptide futhi agonist ka emathunjini guanylate cyclase uhlobo C (GC C), okuyinto ikhipha walandisa guanylin peptide umndeni, ne secretagogue, analgesic nemisebenzi laxative. Lapho ukuphatha temlomo, linaclotide lubopha futhi oyenza GC C receptor elise phezu luminal we epithelium emathunjini. Lokhu kwandisa lokuhlushwa intracellular eyindilinga guanosine monophosphate (cGMP), elisuselwa guanosine triphosphate (GTP). cGMP oyenza isebenze fibrosis cystic transmembrane conductance Regulator (CFTR) futhi kuvusa uketshezi of chloride futhi Bicarbonate ku mafutha anciphisa isikhala esingaphakathi emathunjini. Lokhu kwenza i-sodium excretion ku mafutha anciphisa isikhala esingaphakathi nemiphumela ekwandeni emathunjini uketshezi uketshezi. Lokhu ekugcineni ngesivinini GI elisendleleni okuqukethwe emathunjini, ngcono wamathumbu ukunyakaza futhi aqede ukuqunjelwa. Ukwandiswa extracellular amazinga cGMP ingase futhi nethonya umphumela antinociceptive, ngokusebenzisa i njengeyozelwe indlela kodwa hhayi cacisa ngokugcwele, lokho kungase kuhilele ukushintshashintsha kwezwi of nociceptors ezitholakele ku colonic afferent ubuhlungu zesivikelo sesifuba. Linaclotide is kancane matasa kusukela ipheshana GI.
