Linaclotide
koko
- Linaclotide Mimọ
- julọ ti ifarada owo
- CAS # 851199-59-2
awọn ọna alaye
- Orukọ: Linaclotide
- CasNo: 851199-59-2
- Molikula agbekalẹ: C59H79N15O21S6
- Irisi: funfun lulú
- Ohun elo: lo fun curing àìrígbẹyà
- DeliveryTime: tọ sowo
- Package: gẹgẹ bi onibara ká ibeere
- Port: Shenzhen
- ProductionCapacity: 1 kilogram / osù
- Ti nw: 98%
- Ibi: 2 ~ 8 ℃. ni idaabobo lati ina
- Transportation: nipa air
- LimitNum: 1 Giramu
superiority
awọn alaye
Ọja: Linaclotide
synonym: Linaclotide roba
CAS No.: 851199-59-2
molikula agbekalẹ: C59H79N15O21S6
molikula àdánù: 1526,8
Irisi: White lulú
Purity:> 98%
ọkọọkan: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn -Pro-ala-Cys-Thr-Gly-Cys-Tyr-OH
Linaclotide ni a sintetiki, mẹrinla amino acid ohun elo ọlọjẹ ara ati agonist ti oporoku guanylate cyclase iru C (GC-C), eyi ti o jẹ structurally ti o ni ibatan si awọn guanylin ohun elo ọlọjẹ ara ebi, pẹlu secretagogue, analgesic ati laxative akitiyan. Lori roba isakoso, linaclotide sopọ si ati activates GC-C iṣan be lori luminal dada ti awọn oporoku epithelium. Eleyi mu ki awọn fojusi ti inuselula salayipo guanosine monophosphate (cGMP), eyi ti o ti yo lati guanosine triphosphate (GTP). cGMP activates awọn cystic fibirosis transmembrane conductance eleto (CFTR) ati stimulates awọn yomijade ti kiloraidi ati bicarbonate sinu oporoku lumen. Eleyi nse soda excretion sinu lumen ati awọn esi ni pọ si oporoku ito yomijade. Eleyi be accelerates GI irekọja si ti oporoku akoonu ti, se ifun ronu ati relieves àìrígbẹyà. Alekun ita ẹya-ara cGMP ipele le tun exert ohun antinociceptive ipa, nipasẹ ohun bi ti sibẹsibẹ ko ni kikun elucidated siseto, ti o le fa awose ti nociceptors ri lori colonic afferent irora okun. Linaclotide ti wa ni minimally o gba lati awọn GI ngba.
