Linaclotide
keywords
- Linaclotide Base
- feem ntau pheej yig tus nqi
- CAS # 851199-59-2
ceev Paub meej
- ProName: Linaclotide
- CasNo: 851199-59-2
- Molecular Formula: C59H79N15O21S6
- Tsos: dawb hmoov
- Daim ntawv: siv rau Tua cem quav
- DeliveryTime: pab zaub mov xa tuaj
- Pob: raws li tus neeg muas zaub uas yuav tsum tau
- Chaw nres nkoj: Shenzhen
- ProductionCapacity: 1 kilogram / rau lub Hlis
- Purity: 98%
- Cia: 2 ~ 8 ℃. kev tiv thaiv los ntawm lub teeb
- Tsheb thauj mus los: los ntawm huab cua
- LimitNum: 1 gram
superiority
Paub meej
Khoom: Linaclotide
yaj: Linaclotide acetate
CAS No.: 851199-59-2
Molecular Formula: C59H79N15O21S6
Molecular Nyhav: 1526,8
Tsos: Dawb hmoov
Purity:> 98%
lawv liag: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Nug -Pro-ALA-Cys-THR-Gly-Cys-Tyr-OH
Linaclotide yog ib tug hluavtaws, kaum plaub amino acid peptide thiab agonist ntawm plab hnyuv guanylate cyclase hom C (GC-C), uas yog structurally txog lub guanylin peptide tsev neeg, nrog secretagogue, analgesic thiab laxative kev ua ub no. Thaum qhov ncauj cov thawj coj, linaclotide uake mus thiab activates GC-C receptors nyob rau lub luminal nto ntawm lub plab hnyuv epithelium. Qhov no yuav tsub lub concentration ntawm intracellular cyclic guanosine monophosphate (cGMP), uas yog derived ntawm guanosine triphosphate (GTP). cGMP activates cystic fibrosis transmembrane conductance regulator (CFTR) thiab nkoos lub tso pa tawm ntawm chloride thiab bicarbonate mus rau hauv lub plab hnyuv lumen. Qhov no yeej txhawb sodium feem mus rau hauv lub lumen thiab tau nyob rau hauv ntau zog plab hnyuv kua secretion. Qhov no thaum kawg accelerates GI transit ntawm plab hnyuv txheem, pab txoj kev plob tsis so tswj zog thiab relieves cem quav. Nce extracellular cGMP theem kuj pheev ib antinociceptive nyhuv, los ntawm ib tug li ntawm tsis tau tsis siab elucidated mechanism, uas tej zaum yuav koom nrog tes taws los piav ntawm nociceptors nyob rau colonic afferent mob fibers. Linaclotide yog tsawg kawg absorbed los ntawm lub GI ib ntsuj av.
