Linaclotide
Mantsoe a sehlooho
- Linaclotide Base
- theko ho fetisisa ka theko e tlaase
- CAS # 851199-59-2
Dintlha Quick
- ProName: Linaclotide
- CasNo: 851199-59-2
- Limolek'hule Mokgwa wa ho Nahana: C59H79N15O21S6
- Ponahalo e: tšoeu phofo
- Kopo: sebediswa bakeng sa ho phekola pipitlelano
- DeliveryTime: thepa e potlakileng
- Sephutheloana: ho latela ditlhoko moreki
- Port: Shenzhen
- ProductionCapacity: 1 dikhilokerama tsa dikarolwana / Khoeli le Khoeli
- Hloekileng: 98%
- Storage: 2 ~ 8 ℃. sireletswa ho khanya
- Lipalangoang: ke moea
- LimitNum: 1 a mob mobile
bophahamo
lintlha
Sehlahisoa: Linaclotide
synonyme: Linaclotide ea acetate
CAS No.: 851199-59-2
limolek'hule Mokgwa wa ho Nahana: C59H79N15O21S6
limolek'hule Weight: 1526,8
Ponahalo: White phofo
e Hloekileng:> 98%
tatelano: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn -Pro-Ala-Cys-rakir-Gly-Cys-Tyr-OH
Linaclotide ke a maiketsetso, metso e mene amino acid e peptide le agonist la mala guanylate cyclase mofuta C (reba-C), e leng structurally amanang ho guanylin peptide lelapa, ka secretagogue, analgesic le mesebetsi laxative. Holim 'a tsamaiso molomo, linaclotide tlama ho le activates reba-C receptors teng ka luminal holim' a epithelium mala. Sena se eketsa ea mahloriso tsa intracellular cyclic guanosine monophosphate (cGMP), e leng le tsoa guanosine diphosphate (GTP). cGMP activates le cystic fibrosis transmembrane conductance regulator (CFTR) le di hlohleletsago ea secretion ea chloride le bicarbonate ka lumen le mala. Sena se etsa sodium excretion ka lumen le ho fella ka eketseha mala secretion mokelikeli. Ena qetellong eketsa GI kangoo la tse ka hare mala, ntlafatsa mantle a mokhatlo oa le lopollang pipitlelano. Eketseha kantle ho sele cGMP maemo a ka boela fana ka ama antinociceptive, ka e ka ba mochine e-s'o ka botlalo tlhaloseditswe ke, e le hore 'na sa akarelletsa diileketerone tsa nociceptors fumanehileng colonic likhoele afferent bohloko. Linaclotide e minimally ananelang pampitšaneng GI.
