Linaclotide
amagama
- Linaclotide Base
- kakhulu ngexabiso elifikelelekayo
- CAS # 851199-59-2
Quick Iinkcukacha
- ProName: Linaclotide
- CasNo: 851199-59-2
- Ifomula Ezinto: C59H79N15O21S6
- Inkangeleko: powder emhlophe
- Isicelo: esetyenziselwa ephilisa ukuqhina
- DeliveryTime: ngolwandle olungele ukusebenza
- Iphakheji: ngokweemfuno zabathengi xa
- Port: Shenzhen
- ProductionCapacity: 1 kg / Inyanga
- Purity: 98%
- Storage: 2 ~ 8 ℃. ekhuselweyo ekukhanyeni
- Zokuhamba: ngomoya
- LimitNum: 1 Igram
ukuphakama
iinkcukacha
Product: Linaclotide
ntonye: Linaclotide acetate
CAS No.: 851199-59-2
Formula eziphilayo: C59H79N15O21S6
Ezinto Ubunzima: 1526,8
Inkangeleko: White powder
Purity:> 98%
Ukulandelelanisa: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn -Pro-Ala-Cys-thr-Gly-Cys-Tyr-OH
Linaclotide i zokwenziwa, elinesine acid acid peptide kunye agonist of wamathumbu uhlobo guanylate cyclase C (C.-C), nto leyo ezakheke ehlobene peptide usapho guanylin, kunye secretagogue, iintlungu kunye nemisebenzi isisu. Phezu ulawulo ngomlomo, linaclotide enebana kwaye isebenze GC-C receptors ibekwe phezu luminal kumphezulu epithelium emathunjini. Oku kwandisa uyazikhomba intracellular elibujikele guanosine monophosphate (cGMP), ethatyathwe guanosine triphosphate (GTP). cGMP iyazingenela esinganyangekiyo abanesigulo transmembrane conductance Regulator (CFTR) kwaye lukwakhuthaza secretion of chloride kunye yesoda kungena sayo emathunjini. Oku kukhuthaza sodium zinomgutyulo kulo mithambo kunye neziphumo ekwandeni secretion emathunjini fluid. Oku ibalekisa GI sendleleni lweziqulatho isisu, iphucula intshukumo kwesisu nokuphelisa nokuqunjelwa. Kumanqanaba cGMP extracellular nabo ngamandla nempembelelo antinociceptive, ngokusebenzisa i njengokuba balo matshinana kodwa hayi cacisa ngokupheleleyo, oko kusenokuquka kwezwi of nociceptors afumaneka kwi kwimicu iintlungu afferent colonic. Linaclotide ke kancinane etsalwe iphecana GI.
