Derivatization of fatty acids in the discovery of peptide and protein drugs

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Peptides and proteins are widely used to treat a variety of diseases, but they usually have to be injected and their effect is short-lived. These shortcomings of native structures can be eliminated with the help of molecular engineering, but this is a difficult task. Molecular engineering techniques, originally applied to insulin and now successfully applied to several biopharmaceuticals, require the derivatization of peptides and proteins from fatty acids. The specific characteristics and location of the attached fatty acids may provide different elongation mechanisms. In addition, this technology may provide a long half-life after oral administration of peptide drugs, may alter the distribution of peptides, and may have the potential for tissue targeting. With the inherent safety of fatty acids and well-defined chemical properties, this technology provides a versatile approach to peptide and protein drug discovery.
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Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides. Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides. Zorzi, A., Middendorp, S.J., Wilbs, J., Dale, K. and Haynes, S. Acylated heptapeptide binds albumin with high affinity, and its use as a label provides a long-acting peptide. Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. 酰化七肽以高亲和力结合白蛋白,并作为标签提供长效肽。 Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. 鎄化七peptide以高亲和力设计白白约筒,使用于设计手机长整线等。 Zorzi, A., Middendorp, S.J., Wilbs, J., Dale, K. and Haynes, S. Acylated heptapeptides bind albumin with high affinity and serve as labels for long-acting peptide delivery. Nat. communicate 8, 16092 (2017).


Post time: Sep-08-2022
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