Orukọ Kemikali: (S) -N- ((3R,4S,5S) -1- ((S) -2- (1R,2R) -3- ((1S,2R) -1-hydroxy-1-phenylpropan-2-yl) amino) -1-methoxy-2-methyl-3-oxopropyl) p yrrolidin-1-yl) -3-methoxy-5-methyl-1-oxoheptan-4-yl) -N,3-dimethyl-2-((S) -3-methyl-2- (methylamino) butanamido) butanamide
Iwọn Molikula: 717.98
Agbekalẹ: C39H67N5O7
CAS: 474645-27-7
Solubility: DMSO to 20 mM

Monomethyl Auristatin E jẹ adolastatin-10itọsẹ peptide pẹlu iṣẹ antimitotic ti o lagbara ati iṣẹ antineoplastic ti o pọju gẹgẹbi apakan ti conjugate antibody-oògùn (ADC). Monomethyl auristatin EMMAE) sopọ mọ tubulin, awọn bulọọki tubulin polymerization, ati idilọwọ iṣelọpọ microtubule, eyiti o yọrisi idalọwọduro mejeeji ti apejọ spindle mitotic ati imuni ti awọn sẹẹli tumo ni ipele M ti iyipo sẹẹli. Lati dinku majele ti ati mu iṣẹ ṣiṣe pọ si,MMAEti wa ni idapọ, nipasẹ ọna asopọ peptide kan ti o le kuro, si antibody monoclonal kan ti o fojusi pataki tumo alaisan kan. Asopọmọra jẹ iduroṣinṣin ni miliọnu extracellular ṣugbọn o ti di ni imurasilẹ lati tu silẹMMAEatẹle ifaramọ ati inu inu ADC nipasẹ awọn sẹẹli afojusun.