Nomen Chemicum: (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamidum
Pondus Moleculare: 717.98
Formula: C39H67N5O7
CAS: 474645-27-7
Solubilitas: DMSO usque ad 20 mM

Monomethyl Auristatinum E estdolastatinum-10Derivatum peptidicum cum potenti activitate antimitotica et potentiali activitate antineoplastica ut pars coniugati anticorporis-medicamenti (ADC). Monomethylauristatin E (MMAE) tubulino se iungit, polymerizationem tubulini inhibet, et formationem microtubulorum inhibet, quod et perturbationem coetus fusi mitotici et sistionem cellularum tumoris in phase M cycli cellularis efficit. Ad toxicitatem minuendam et efficaciam augendam,MMAEConiungitur, per ligamen peptidicum scindibile, cum anticorpore monoclonali quod tumorem aegroti specifice petit. Ligamen in ambitu extracellulari stabilis est, sed facile scinditur ad liberandum.MMAEpost ligationem et internalizationem ADC a cellulis destinatis.