Orukọ Kemikali:(S) -2- ((2R, 3R) -3- ((S) -1- ((3R,4S,5S) -4- ((S) -N,3-dimethyl-2- ((S) -3-methyl-2- (methylamino) butanamido) butanamido) -3-methoxy-5-methylheptanoyl) pyrrolidin-2-yl) -3-methproxy-2-3-3-methproxy acid-propamiyl-3-3-methyl.

Ìwúwo Molikula:731.96
Fọọmu:C39H65N5O8
CAS#:141205-32-5
Solubility:DMSO to 20 mM

Ti ibi aṣayan iṣẹ-ṣiṣe
Monomethyl auristatin F (MMAF) tabi desmethyl-auristatin F jẹ aṣoju egboogi-tubulin ti o ṣe idiwọ pipin sẹẹli nipa didi polymerization ti tubulin. O jẹ tuntunauristatin itọsẹpẹlu idiyele C-terminal phenylalanine ti o dinku iṣẹ ṣiṣe cytotoxic rẹ ni akawe si ẹlẹgbẹ ti ko gba agbara, monomethyl auristatin E (MMAE). Ni afikun, ẹgbẹ N-terminal amino ni nikanọkanaropo methyl dipo meji bi ninuauristatin Ffunrararẹ.