Chemical Name: (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)p yrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide
Molecular uremu: 717.98
Nzira: C39H67N5O7
CAS: 474645-27-7
Solubility: DMSO kusvika ku20 mM

Monomethyl Auristatin E ndiye adolastatin-10peptide inobva kune ine simba antimitotic chiitiko uye inogona kuita antineoplastic chiitiko sechikamu cheantibody-drug conjugate (ADC). Monomethyl auristatin E (MMAE) inosunga ku tubulin, inovhara tubulin polymerization, uye inhibits microtubule kugadzirwa, izvo zvinoguma nekuvhiringidzwa kwese mitotic spindle assembly uye kusungwa kwebundu masero muM chikamu chesero cycle. Kuderedza toxicity uye kuwedzera kushanda zvakanaka,MMAEinosanganiswa, kuburikidza neinotsemuka peptide linker, kune monoclonal antibody inonangana nebundu remurwere. Iyo linker yakagadzikana mune iyo extracellular milieu asi inonamirwa nyore kusununguraMMAEkutevera kusunga uye kuiswa mukati kweADC nemasero anotarirwa.