Nomen Chemicum:Acidum (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoicum

Pondus Moleculare:731.96
Formula:C39H65N5O8
Numerus CAS:141205-32-5
Solubilitas:DMSO usque ad 20 mM

Actio Biologica
Monomethylauristatin F (MMAF) vel desmethylauristatin F est medicamentum antitubulinum quod divisionem cellularum inhibet polymerizationem tubulini impediendo. Est novum...auristatinum derivativumcum phenylalanina C-terminali onerata quae eius actionem cytotoxicam attenuat comparata cum contraparte non onerata, monomethylauristatino E (MMAE). Praeterea, grex amino N-terminalis tantum habetunussubstituens methylicus loco duorum ut inauristatin Fse ipsum