Molecular Formula：

C76H104N18O19S2

Relative Molecular Mass：

1637.90 g/mol

CAS-Number：

38916-34-6 (net)

Long-term Storage：

-20 ± 5°C

Synonyms：

Somatostatin-14; SRIF-14;
Somatotropin Release-Inhibiting Factor; SRIF

Sequence：

H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH acetate salt (Disulfide bond)

Fields of Application：

Ulcer bleeding
Hemorrhagic gastritis
Postoperative pancreatic and duodenal fistulae
Variceal hemorrhage

Active Substance：

Somatostatin (SRIF) is an inhibitor of growth hormone release from the anterior pituitary and hence an antagonist of GRF.Somatostatin suppresses the release of a variety of other hormones involved in the regulation of important physiological functions of the gastrointestinal tract. Somatostatin also inhibits TSH production.Somatostatin is a 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.

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