Molecular Formula：

C49H62N10O16S3

Relative Molecular Mass：

1143.29 g/mol

CAS-Number：

25126-32-3 (net)

Long-term Storage：

-20 ± 5°C

Synonyms：

CCK-8; Cholecystokinin Octapeptide; (Des-Pyr1,Des-Gln2,Met5)-Caerulein

Application:
Sincalide is a cholecystokinetic drug administered by injection to aid in diagnosing disorders of the gallbladder and pancreas. It is the 8-amino acid C-terminal fragment of cholecystokinin, also known as CCK-8. Endogenous cholecystokinin is a gastrointestinal peptide hormone responsible for stimulating the digestion of fat and protein. When injected intravenously, sincalide produces a substantial reduction in gallbladder size by causing this organ to contract. The evacuation of bile that results is similar to that which occurs physiologically in response to endogenous cholecystokinin. Furthermore, sincalide stimulates pancreatic secretion of bicarbonate and enzymes.

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