Awọn iru ẹrọ imọ-ẹrọ peptide Synthesis
Awọn peptides gigun (30-60 amino acids), awọn peptides eka (lipopeptides, glycopeptides), awọn peptides cyclic, awọn peptides amino acid adayeba, awọn peptide-nucleic acids, awọn ohun elo peptide-kekere, awọn ọlọjẹ peptide, peptide-radionuclides, ati bẹbẹ lọ.
Iṣagbepọ peptide Alakoso-pipa (SPPS)
Iṣagbepọ peptide Alakoso Liquid-Alakoso (LPPS)
Agbepọ peptide Ipele Olomi-Ile (L/SPPS)
Ilana Idaabobo Ẹgbẹ ti o kere julọ fun SPPS (MP-SPPS)
Irọrun ilana naa nipa idinku lilo awọn ẹgbẹ aabo orthogonal lakoko iṣelọpọ; dinku idiyele ti awọn reagents gbowolori (gẹgẹbi Fmoc/tBu); dojuti awọn aati ẹgbẹ (gẹgẹbi idabobo ti tọjọ).
Ile-iṣẹ naa ti fi ẹsun ju awọn ohun elo aami-iṣowo 60 lọ, pẹlu awọn ami-iṣowo mẹrin ni European Union ati mẹta ni Amẹrika, ati pe o ti gba awọn iforukọsilẹ aṣẹ-lori fun awọn iṣẹ mẹrin.
Awọn iru ẹrọ Iyipada Peptide
Nipa iṣafihan awọn ẹgbẹ olutọpa (gẹgẹbi awọn ẹgbẹ fluorescent, biotin, radioisotopes) sinu awọn peptides, awọn iṣẹ bii titọpa, wiwa, tabi ijẹrisi ibi-afẹde le ṣaṣeyọri.
PEGylation ṣe iṣapeye awọn ohun-ini elegbogi ti awọn peptides (fun apẹẹrẹ, gigun igbesi aye idaji ati idinku ajẹsara).
Awọn iṣẹ Iṣọkan Peptide (P-Oògùn Conjugate)
Faaji-ero mẹta ti eto itọju ailera ti a fojusi:
Ifojusi Peptide: Ni pato sopọ si awọn olugba / awọn antigens lori oju awọn sẹẹli ti o ni aisan (gẹgẹbi awọn sẹẹli alakan);
Linker: Awọn afara peptide ati oogun naa, ti n ṣe ilana idasilẹ oogun (apẹrẹ ti o le / ti kii-cleavable);
Isanwo Oògùn: Pese awọn cytotoxins tabi awọn paati itọju ailera (gẹgẹbi awọn oogun chemotherapeutic, radionuclides).
Awọn iru ẹrọ imọ-ẹrọ Fọọmu Peptide
Awọn ọna ikojọpọ oogun: Lilo awọn imọ-ẹrọ ifijiṣẹ ilọsiwaju gẹgẹbi awọn liposomes, awọn micelles polymeric, ati awọn ẹwẹ titobi.
Eto ifijiṣẹ oogun tuntun ṣe pẹ ni pataki ni iye itusilẹ oogun vivo, muu mu ilana iwọn lilo iṣapeye ṣiṣẹ, nitorinaa imudara ifaramọ itọju alaisan.
Gba 2D-LC imọ-ẹrọ sisọ lori ayelujara lati ṣaṣeyọri idanimọ daradara ti awọn aimọ idiju. Imọ-ẹrọ yii le yanju iṣoro ibaramu ni imunadoko laarin ifipamọ - ti o ni awọn ipele alagbeka ninu ati wiwa ibi-iwoye.
Ijọpọ ti Apẹrẹ ti Awọn adanwo (DoE), iboju adaṣe adaṣe, ati awọn imọ-ẹrọ awoṣe iṣiro ṣe alekun imunadoko idagbasoke ọna itupalẹ ati agbara abajade.
Awọn agbara mojuto
1.Ọja Abuda Analysis
2.Analytical Ọna Idagbasoke ati afọwọsi
3.Stability Study
4.Idamọ Profiling Impurity
JY FISTM ìwẹnumọ Technology Platform
1.Chromatography ti o tẹsiwaju
Ti a fiwera si kiromatografi ipele, o funni ni awọn anfani ti agbara epo kekere, ṣiṣe iṣelọpọ ti o ga, ati iwọn ti o ga julọ.
2.High-Performance Liquid Chromatography System1.
3.Iyara Iyapa Iyapa pẹlu iyipada si awọn peptides oniruuru
Ṣe itọju iduroṣinṣin igbekalẹ peptide ati bioactivity, ni irọrun tun ṣe pẹlu omi.
Ni pataki diẹ sii daradara ju lyophilization, pẹlu iwọn iyara si awọn ipele iṣelọpọ ile-iṣẹ.
Recrystallization ti wa ni akọkọ oojọ ti ni Liquid-Alakoso Peptide Synthesis (LPPS) lati gba awọn peptides mimọ-giga ati awọn ajẹkù lakoko mimu iṣapeye awọn ẹya gara nigbakan, nfunni ni awọn anfani to munadoko.
Awọn agbara mojuto
1.Ọja Abuda Analysis
2.Analytical Ọna Idagbasoke ati afọwọsi
3.Stability Study
4.Idamọ Profiling Impurity
Lab ati Pilot Equipments
LAB
Adaṣiṣẹpọ Peptide Synthesizer ni kikun
20-50 L reactors
YXPPSTM
Prep-HPLC (DAC50 – DAC150)
Awọn gbẹgbẹ di didi (0.18 m2 – 0.5m2)
PILOT
3000L SPPS
500L-5000L LPS
Igbaradi-HPLC DAC150 - DAC 1200mm
Laifọwọyi Gbigba System
Awọn olugbẹgbẹ di didi
Sokiri Drier
