TECHNOLOGY PLATFORMS

I-Peptide Synthesis Technology Platforms

Ama-Peptides Ayinkimbinkimbi kanye ne-Peptidomimetic Chemical Synthesis

Ama-peptide amade (ama-amino acid angama-30 - 60), ama-peptides ayinkimbinkimbi (ama-lipopeptides, ama-glycopeptides), ama-peptide angama-cyclic, ama-peptide angewona emvelo amino acid, ama-peptide-nucleic acid, ama-molecule e-peptide-amancane, ama-peptide-protein, ama-peptide-radionuclides, njll.

I-Peptide Synthesis Technology Platforms

I-Solid-Phase Peptide Synthesis(SPPS)
I-Liquid-Phase Peptide Synthesis (LPPS)
I-Liquid-Soild Phase Peptide Synthesis (L/SPPS)
Isu Elincane Leqembu Lokuvikela le-SPPS (MP-SPPS)
Yenza kube lula inqubo ngokunciphisa ukusetshenziswa kwamaqembu okuvikela ama-orthogonal ngesikhathi sokuhlanganiswa; ukunciphisa izindleko zama-reagents abizayo (njenge-Fmoc/tBu); vimbela ukusabela okuseceleni (njengokuvikela ngaphambi kwesikhathi).

I-Hybrid-Phase Synthesis(HPPS)

Le nkampani ifake izicelo zezimpawu zokuhweba ezingaphezu kuka-60, okuhlanganisa nezimpawu zokuthengisa ezine e-European Union nezintathu e-United States, futhi ithole ukubhaliswa kwamalungelo okushicilela emisebenzi emine.

Amapulatifomu okuguqula i-Peptide

Ubunjiniyela bokulebula

Ngokwethula amaqembu e-tracer (njengamaqembu e-fluorescent, i-biotin, ama-radioisotopes) kuma-peptide, imisebenzi efana nokulandelela, ukutholwa, noma ukuqinisekiswa okuqondisiwe kungafinyelelwa.

I-PEGylated Peptides

I-PEGylation ithuthukisa izakhiwo ze-pharmacokinetic zama-peptide (isb, ukwandisa uhhafu wempilo kanye nokunciphisa ukuzivikela komzimba).

I-Conjugation Technology

Peptide Conjugation Services (P-Drug Conjugate)

Izakhiwo ezinezici ezintathu zohlelo lokwelapha oluhlosiwe:

I-Peptide Eqondisayo: Ibophezela ngokukhethekile kuma-receptors / ama-antigen ebusweni bamaseli anesifo (njengamaseli omdlavuza);

I-Linker: Ibhuloho i-peptide nomuthi, ilawula ukukhishwa kwezidakamizwa (umklamo ohlukanisekayo/ongahlukaniseki);

Ukukhokhelwa Kwezidakamizwa: Iletha ama-cytotoxins noma izingxenye zokwelapha (njengezidakamizwa ze-chemotherapeutic, ama-radionuclides).

I-Peptide Formulation Technology Platforms

Oral Delivery System

Amasistimu Wokulayisha Izidakamizwa: Kusetshenziswa ubuchwepheshe bokuletha obuthuthukile obufana nama-liposomes, ama-polymeric micelles, nama-nanoparticles.

Ubuchwepheshe Bokukhishwa Okuqhubekayo Okudala Basebenza

Uhlelo olusha lokulethwa kwezidakamizwa lwandisa ngokuphawulekayo ubude besikhathi sokukhululwa kwezidakamizwa, luvumela ukulawulwa kwemvamisa yomthamo, ngaleyo ndlela kuthuthukise ukubambelela ekwelashweni kwesiguli.

I-Multidimensional Chromatography

Adopt 2D-LC online desalting technology ukuze uzuze ukuhlonza okusebenzayo kokungcola okuyinkimbinkimbi. Lobu buchwepheshe bungaxazulula ngempumelelo inkinga yokuhambisana phakathi kwebhafa - equkethe izigaba zeselula nokutholwa kwe-mass spectrometry.

I-FUSION®(Isistimu Yokuhlaziya Ehlakaniphile)

Ukuhlanganiswa kwe-Design of Experiments (DoE), ukuhlola okuzenzakalelayo, kanye nobuchwepheshe bokumodela bezibalo kukhulisa kakhulu ukusebenza kahle kokuthuthukiswa kwendlela yokuhlaziya kanye nokuqina kwemiphumela.

I-Analytical Development Platform

Amakhono Abalulekile
1.Ukuhlaziywa Kokulinganisa Komkhiqizo
2.Ukuthuthukiswa Kwendlela Yokuhlaziya Nokuqinisekisa
3.Isifundo Sokuzinza
4.Ukungcola Kokuhlonza Iphrofayela

I-JY FISTM Yokuhlanza Ipulatifomu Yobuchwepheshe

Ukwehlukana/Ubuchwepheshe Bokuhlanzwa

1.I-Chromatography eqhubekayo
Uma kuqhathaniswa ne-batch chromatography, inikeza izinzuzo zokusetshenziswa kwe-solvent ephansi, ukusebenza kahle kokukhiqiza okuphezulu, kanye nokuqina okuphezulu.
2.I-High-Performance Liquid Chromatography System1.
3.Isivinini sokuhlukanisa esisheshayo esivumelana nezimo kuma-peptide ahlukahlukene

Ukuthuthukiswa Kwenqubo ye-Lyophilisation

Igcina ubuqotho besakhiwo se-peptide kanye ne-bioactivity, ihlanganiswa kalula namanzi.

Ukuthuthukiswa Kwenqubo Yesifutho

Isebenza kahle kakhulu kune-lyophilization, enokukala ngokushesha emazingeni okukhiqiza ezimbonini.

Ukwenziwa kabusha kwekristalu

I-recrystallization isetshenziswa ngokuyinhloko kumasu we-Liquid-Phase Peptide Synthesis (LPPS) ukuze kutholwe ama-peptide ahlanzekile nezingcezu kuyilapho ngesikhathi esifanayo kulungiswa izakhiwo zekristalu, zinikeza izinzuzo ezingabizi kakhulu.

I-Analytical Development Platform

Amakhono Abalulekile
1.Ukuhlaziywa Kokulinganisa Komkhiqizo
2.Ukuthuthukiswa Kwendlela Yokuhlaziya Nokuqinisekisa
3.Isifundo Sokuzinza
4.Ukungcola Kokuhlonza Iphrofayela