IIPLAFOM ZOBUGCISA-Shenzhen JYMed Technology Co., Ltd

I-Peptide Synthesis Technology Platforms

IiPeptides eziyinkimbinkimbi kunye nePeptidomimetic Chemical Synthesis

Iipeptide ezinde (30 - 60 amino acids), iipeptides ezintsonkothileyo (lipopeptides, glycopeptides), peptides cyclic, non-natural amino acid peptides, peptide-nucleic acids, peptide-imolekyuli ezincinci, peptide-proteins, peptide-radionuclides, njl.

I-Peptide Synthesis Technology Platforms

I-Solid-Phase Peptide Synthesis (SPPS)
I-Liquid-Phase Peptide Synthesis (LPPS)
I-Liquid-Soild Phase Peptide Synthesis (L/SPPS)
Ubuncinci beQela loKhuselo lweQela leSPPS (MP-SPPS)
Yenza lula inkqubo ngokunciphisa ukusetyenziswa kwamaqela okukhusela i-orthogonal ngexesha lokudibanisa; ukunciphisa iindleko zeerejenti ezibizayo (ezifana neFmoc/tBu); inqanda ukusabela kwecala (njengokukhuselwa kwangaphambi kwexesha).

I-Hybrid-Phase Synthesis(HPPS)

Inkampani ifake izicelo zentengiso ezingaphezu kwe-60, kubandakanywa iimpawu zokuthengisa ezine kwi-European Union kunye nezintathu e-United States, kwaye ifumene ukubhaliswa kwamalungelo okushicilela kwimisebenzi emine.

Iiplatform zokuguqulwa kwePeptide

Ubunjineli bokuLayibhile

Ngokuzisa amaqela e-tracer (afana namaqela e-fluorescent, i-biotin, i-radioisotopes) kwiipeptides, imisebenzi enjengokulandelela, ukukhangela, okanye ukuqinisekiswa okujoliswe kuyo kunokufezekiswa.

I-PEGylated Peptides

I-PEGylation ilungiselela iipropathi ze-pharmacokinetic ze-peptides (umzekelo, ukwandisa isiqingatha sobomi kunye nokunciphisa i-immunogenicity).

Itekhnoloji yokudibanisa

Iinkonzo zokudibanisa i-Peptide (P-Drug Conjugate)

Uyilo lwezinto ezintathu zenkqubo yonyango ekujoliswe kuyo:

I-Peptide ekujoliswe kuyo: Ngokukodwa ibophelela kwi-receptors / i-antigens ebusweni beeseli ezigulayo (ezifana neeseli zomhlaza);

Ikhonkco: Ibhulorho i-peptide kunye nechiza, ilawula ukukhutshwa kweziyobisi (uyilo olucandekayo / olungenakucandeka);

Ukuhlawulwa kweziyobisi: Ihambisa i-cytotoxins okanye amacandelo onyango (afana neziyobisi ze-chemotherapeutic, i-radionuclides).

IiPlatform zeTekhnoloji zokuSebenza kwePeptide

Inkqubo yokuhanjiswa komlomo

IiNkqubo zokuLayishwa kweziyobisi: Ukusebenzisa itekhnoloji yonikezelo oluphambili olunje nge-liposomes, ii-polymeric micelles, kunye ne-nanoparticles.

ITekhnoloji yokuKhupha ixesha elide eZinzileyo

Inkqubo yokuhanjiswa kwechiza entsha yongeza ngokubonakalayo ubude bexesha lokukhutshwa kwechiza, ivumela ukulawulwa kwe-dosing frequency ephuculweyo, ngokwenjenjalo iphucula ukubambelela kunyango lwesigulane.

I-Multidimensional Chromatography

Yamkela itekhnoloji ye-2D-LC ye-intanethi ye-desalting ukufezekisa ukuchongwa okusebenzayo kobumdaka obuntsonkothileyo. Le teknoloji inokusombulula ngokufanelekileyo ingxaki yokuhambelana phakathi kwe-buffer-equlethe izigaba zeselula kunye nokufunyanwa kwe-mass spectrometry.

I-FUSION®(Inkqubo yoHlahlelo olukrelekrele)

Ukudityaniswa koYilo loVavanyo (DoE), ukuhlolwa okuzenzekelayo, kunye nobugcisa bokulinganisa amanani kuphucula kakhulu indlela yohlalutyo yophuhliso kunye nokomelela kweziphumo.

Iqonga loPhuhliso loHlahlo

Izakhono ezingundoqo
1.Uhlalutyo lweempawu zeMveliso
2.UHlalutyo lweNdlela yoPhuhliso kunye nokuQinisekisa
3.Isifundo sozinzo
4.Ukuchongwa kweProfayili yokungacoceki

I-JY FISTM yoCwangciso lweTekhnoloji yePlatifomu

Ukwahlula/Ubuchwephesha bokucoca

1.IChromatography eqhubekayo
Xa kuthelekiswa ne-batch chromatography, ibonelela ngeengenelo zokusetyenziswa kwe-solvent esezantsi, ukusebenza kakuhle kwemveliso, kunye nokwehla okuphezulu.
2.INkqubo yeChromatography yoLiquid ePhezulu-Ukusebenza1.
3.Isantya sokwahlula ngokukhawuleza kunye nokuguquguquka kwiipeptides ezahlukeneyo

Uphuhliso lweNkqubo yeLyophilization

Igcina isidima solwakhiwo lwe-peptide kunye ne-bioactivity, iphinda ibunjwe ngokulula ngamanzi.

Uphuhliso lweNkqubo yokutshiza

Isebenza ngokuphawulekayo ngakumbi kune-lyophilization, kunye nokukhawuleza ngokukhawuleza kumanqanaba okuvelisa amashishini.

Recrystallization

I-recrystallization isetyenziswa ikakhulu kwi-Liquid-Phase Peptide Synthesis (LPPS) izicwangciso zokufumana iipeptide ezicocekileyo kunye namaqhekeza ngelixa ngaxeshanye kulungiswa izakhiwo zekristale, zibonelela ngeenzuzo ezingabizi kakhulu.

Iqonga loPhuhliso loHlahlo

Izakhono ezingundoqo
1.Uhlalutyo lweempawu zeMveliso
2.UHlalutyo lweNdlela yoPhuhliso kunye nokuQinisekisa
3.Isifundo sozinzo
4.Ukuchongwa kweProfayili yokungacoceki