Peptide Synthesis Technology Platforms
Li-peptide tse telele (30 - 60 amino acid), li-peptide tse rarahaneng (lipopeptides, glycopeptides), li-peptide tsa cyclic, li-peptide tseo e seng tsa tlhaho tsa amino acid, li-peptide-nucleic acid, limolek'hule tse nyane tsa peptide, liprotheine tsa peptide, peptide-radionuclides, jj.
Solid-Phase Peptide Synthesis(SPPS)
Liquid-Phase Peptide Synthesis (LPPS)
Liquid-Soild Phase Peptide Synthesis (L/SPPS)
Maano a Tlase a Sehlopha sa Tšireletso bakeng sa SPPS (MP-SPPS)
Ho nolofatsa ts'ebetso ka ho fokotsa ts'ebeliso ea lihlopha tsa ts'ireletso ea orthogonal nakong ea synthesis; fokotsa litšenyehelo tsa li-reagents tse theko e boima (tse kang Fmoc/tBu); thibela maikutlo a mahlakoreng (joalo ka ho thibela pele ho nako).
Khampani e kentse likopo tse fetang 60 tsa matšoao a khoebo, ho kenyeletsoa matšoao a mane European Union le a mararo United States, 'me e fumane lingoliso tsa litokelo tsa litokelo tsa mesebetsi e mene.
Li-platform tsa ho fetola peptide
Ka ho hlahisa lihlopha tsa li-tracer (tse kang lihlopha tsa fluorescent, biotin, radioisotopes) ho li-peptide, mesebetsi e kang ho latedisa, ho lemoha, kapa ho netefatsa netefatso e ka fihlellwa.
PEGylation e ntlafatsa thepa ea pharmacokinetic ea li-peptide (mohlala, ho atolosa halofo ea bophelo le ho fokotsa immunogenicity).
Peptide Conjugation Services (P-Drug Conjugate)
Mehaho ea likarolo tse tharo tsa sistimi e reriloeng ea kalafo:
Targeting Peptide: Ka ho khetheha e tlama ho li-receptor / li-antigen holim'a lisele tse kulang (tse kang lisele tsa kankere);
Linker: E koala peptide le lithethefatsi, e laola ho lokolloa ha lithethefatsi (moqapi o ka qhekellang / o sa qhetsoeng);
Tefo ea Lithethefatsi: E fana ka li-cytotoxins kapa likarolo tsa kalafo (joalo ka lithethefatsi tsa chemotherapeutic, radionuclides).
Peptide Formulation Technology Platforms
Litsamaiso tsa ho Laola Lithethefatsi: Ho sebelisa mekhoa e tsoetseng pele ea ho fana ka thepa e kang liposomes, polymeric micelles, le nanoparticles.
Mokhoa o mocha oa phano ea lithethefatsi o lelefatsa haholo nako ea ho lokolloa ha lithethefatsi, e nolofalletsang taolo e ntlafalitsoeng ea litekanyetso tsa litekanyetso, ka hona e matlafatsa ho khomarela kalafo ea bakuli.
Adopt 2D-LC thekenoloji ea ho tlosa letsoai inthaneteng ho fihlela boitsebahatso bo nepahetseng ba litšila tse rarahaneng. Theknoloji ena e ka rarolla bothata ba tšebelisano lipakeng tsa buffer - e nang le mekhahlelo ea mehala le ponelopele ea "mass spectrometry".
Ho hokahana ha Design of Experiments (DoE), ho itlhahloba ka boiketsetso, le mahlale a lipalo-palo a mohlala ho matlafatsa katleho ea nts'etsopele ea mekhoa ea tlhahlobo le matla a sephetho.
Matla a Konokono
1.Tlhahlobo ea Boitšoaro ba Sehlahisoa
2.Nts'etsopele ea Mokhoa oa Tlhahlobo le netefatso
3.Thuto ea Botsitso
4.Tlhahiso ea Boitsebiso ba Litšila
JY FISTM Ho Hloekisa Technology Platform
1.Chromatography e tsoelang pele
Ha e bapisoa le batch chromatography, e fana ka melemo ea tšebeliso e tlase ea solvent, katleho e phahameng ea tlhahiso, le scalability e phahameng.
2.Setsi se Phahameng sa Liquid Chromatography System1.
3.Lebelo la karohano le potlakileng le ho ikamahanya le maemo ho li-peptide tse fapaneng
E boloka botsitso ba sebopeho sa peptide le bioactivity, e hlophisitsoeng habonolo ka metsi.
E sebetsa hantle haholo ho feta lyophilization, e nang le scalability e potlakileng ho maemo a tlhahiso ea indasteri.
Recrystallization e sebelisoa haholo maqheka a Liquid-Phase Peptide Synthesis (LPPS) ho fumana li-peptide le likhechana tse hloekileng ha ka nako e ts'oanang ho ntlafatsa meaho ea kristale, e fanang ka melemo e theko e tlase.
Matla a Konokono
1.Tlhahlobo ea Boitšoaro ba Sehlahisoa
2.Nts'etsopele ea Mokhoa oa Tlhahlobo le netefatso
3.Thuto ea Botsitso
4.Tlhahiso ea Boitsebiso ba Litšila
Lisebelisoa tsa Lab le Pilot
LABANE
Peptide Synthesizer e Ikemetseng ka Botlalo
20-50 L Reactors
YXPPSTM
Prep-HPLC (DAC50 - DAC150)
Lihatsetsi tsa ho omisa (0.18 m2 - 0.5m2)
MOTSAMAI
3000L SPPS
500L-5000L LPPS
Prep-HPLC DAC150 - DAC 1200mm
Mokhoa o Ikemetseng oa Pokello
Lihatsetsi tsa ho omisa
Spray Drier
