Platforms Technology Peptide Synthesis
peptides dheer (30-60 amino acids), peptides adag (lipopeptides, glycopeptides), peptides cyclic, peptides amino acids dabiiciga ah, peptide-nucleic acids, peptide-molecules peptide-small, peptide-proteins, peptide-radionuclides, iwm.
Wajiga adag ee Peptide Synthesis (SPPS)
Wajiga dareeraha ah ee Peptide Synthesis (LPPS)
Wajiga dareeraha-carka ee Peptide Synthesis (L/SPPS)
Istaraatiijiyada Kooxda Ilaalinta Ugu Yar ee SPPS (MP-SPPS)
Fududeynta habka adoo yareynaya isticmaalka kooxaha ilaalinta orthogonal inta lagu jiro isku-dhafka; hoos u dhig qiimaha reagents qaali ah (sida Fmoc/tBu); joojiso falcelinta dhinaca (sida ilaalinta degdega ah).
Shirkaddu waxay xaraysay in ka badan 60 codsiyo-ganacsiyeedka, oo ay ku jiraan afar calaamadood oo ku yaal Midowga Yurub iyo saddex gudaha Maraykanka ah, waxayna heshay diiwaan-gelinta xuquuqda daabacaadda afar shaqo.
Platforms Beddelka Peptide
Marka la soo bandhigo kooxaha raadraacayaasha (sida kooxaha fluorescent, biotin, radioisotopes) ee peptides, hawlaha sida dabagalka, ogaanshaha, ama xaqiijinta bartilmaameedka ayaa la gaari karaa.
PEGylation waxay wanaajisaa sifooyinka farmashiyaha ee peptides (tusaale, kordhinta nolosha nuska iyo yaraynta difaaca jirka).
Adeegyada Isku xidhka Peptide (P-Drug Conjugate)
Naqshadaynta saddex-qaybood ee nidaamka daawaynta la beegsaday:
Bartilmaameedka Peptide: Waxay si gaar ah ugu xidhan tahay reseptors/antigens ee korka unugyada buka (sida unugyada kansarka);
Xiriiriyaha: Buundooyinka peptide-ka iyo dawada, nidaaminaya siideynta daroogada (naqshad la nadiifin karo/aan-furmi karin);
Qaadashada daroogada: Waxay keentaa cytotoxins ama qaybaha daawaynta (sida daawooyinka kiimikaad, radionuclides).
Platforms Technology Formulation Peptide
Nidaamyada Qaadista Maandooriyaha: Isticmaalka tignoolajiyada gaarsiinta horumarsan sida liposomes, miceles polymeric, iyo nanoparticles.
Nidaamka bixinta dawooyinka cusubi wuxuu si weyn u dheereeyaa muddada sii deynta daawada vivo, taasoo awood u siinaysa habaynta qiyaasta qiyaasta qiyaasta, taas oo kor u qaadeysa u hoggaansanaanta daaweynta bukaanka.
Qaado 2D-LC tignoolajiyada wax lagu nadiifiyo ee khadka tooska ah si aad u hesho aqoonsi hufan oo wasakhda kakan. Farsamadani waxay si wax ku ool ah u xallin kartaa mushkiladda iswaafajinta ee u dhaxaysa kaydinta - ka kooban wejiyada moobilka iyo ogaanshaha spectrometry mass.
Isku dhafka Naqshadeynta Tijaabooyinka (DoE), baarista tooska ah, iyo teknoolojiyadda qaabeynta tirakoobka ayaa si weyn u wanaajinaya hufnaanta horumarinta habka falanqaynta iyo natiijada adkeynta.
Awoodaha Muhiimka ah
1. Falanqaynta Tilmaamaha Alaabta
2. Habka Analytical Development and Validation
3.Daraasadda xasiloonida
4. Aqoonsiga Faafinta Xumaanta
JY FISTM Platform Farsamada Nadiifinta
1.Cromatography joogto ah
Marka la barbar dhigo chromatography Dufcaddii, waxay bixisaa faa'iidooyinka isticmaalka dareeraha hoose, wax soo saarka sare, iyo miisaan sare.
2.Waxqabadka Sare ee Nidaamka Chromatography ee dareeraha ah1.
3.Xawaaraha kala soocida degdega ah oo leh laqabsiga peptides kala duwan
Waxay ilaalisaa hufnaanta qaab dhismeedka peptide iyo bioactivity, si sahal ah dib loogu dhisay biyo.
Si mug leh uga waxtar badan lyophilization, oo leh miisaan degdeg ah ilaa heerarka wax soo saarka warshadaha.
Dib-u-crystallization waxaa ugu horrayn lagu shaqeeyaa xeeladaha Liquid-Phase Peptide Synthesis (LPPS) si loo helo peptides saafi ah iyo jajabyo iyadoo isla markaa la wanaajinayo qaab-dhismeedka crystal, bixinta faa'iidooyin kharash-ool ah.
Awoodaha Muhiimka ah
1. Falanqaynta Tilmaamaha Alaabta
2. Habka Analytical Development and Validation
3.Daraasadda xasiloonida
4. Aqoonsiga Faafinta Xumaanta
Qalabka Shaybaadhka iyo Tijaabada
LAB
Peptide Synthesizer si buuxda u toosan
20-50 L Reactors
YXPPSTM
Prep-HPLC (DAC50 - DAC150)
Qalajiyaha qaboojiyaha (0.18m2 - 0.5m2)
PILOT
3000L SPPS
500L-5000L LPS
Diyaarinta-HPLC DAC150 - DAC 1200mm
Nidaamka Uruurinta Tooska ah
Qalajiyaha qaboojiya
Qalajiyaha buufin
