Peptide Synthesis Technology Platforms
Marefu epeptide (30 - 60 amino acids), yakaoma peptides (lipopeptides, glycopeptides), cyclic peptides, asiri - natural amino acid peptides, peptide-nucleic acids, peptide-diki mamorekuru, peptide-mapuroteni, peptide-radionuclides, nezvimwewo.
Solid-Phase Peptide Synthesis(SPPS)
Liquid-Phase Peptide Synthesis (LPPS)
Liquid-Soild Phase Peptide Synthesis (L/SPPS)
Minimum Protecting Group Strategy yeSPPS (MP-SPPS)
Rerutsa maitiro nekuderedza kushandiswa kwemapoka ekudzivirira orthogonal panguva yekubatanidza; kuderedza mari yemareagents anodhura (akadai seFmoc/tBu); inhibit side reactions (zvakadai sekudzivirira nguva isati yakwana).
Kambani iyi yakamhan'ara zvikumbiro zvinodarika makumi matanhatu, kusanganisira zviratidzo zvina muEuropean Union uye zvitatu muUnited States, uye yakawana kunyoreswa kwekodzero dzemabasa mana.
Peptide Kugadziridza Mapuratifomu
Nekuunza mapoka etracer (akadai semapoka efluorescent, biotin, radioisotopes) mumapeptides, mabasa akadai sekutevera, kuona, kana kutarisisa kwetariro anogona kuwanikwa.
PEGylation inokwidziridza iyo pharmacokinetic zvimiro zvepeptides (semuenzaniso, kuwedzera hafu yehupenyu uye kuderedza immunogenicity).
Peptide Conjugation Services (P-Drug Conjugate)
Zvitatu-zvinhu zvivakwa zveiyo yakanangwa therapy system:
Targeting Peptide: Kunyanya kusungira kune receptors / antigens pamusoro pemasero anorwara (akadai sekenza masero);
Linker: Mabhiriji peptide uye mushonga, kudzora kuburitswa kwezvinodhaka (cleavable/non-cleavable design);
Mishonga Inobhadhara: Inopa cytotoxins kana mishonga yekurapa (senge chemotherapeutic zvinodhaka, radionuclides).
Peptide Formulation Technology Platforms
Drug Loading Systems: Kushandisa tekinoroji yekuburitsa senge liposomes, polymeric micelles, uye nanoparticles.
Iyo yekuvandudza dhizaini yekuendesa zvinodhaka inorebesa zvakanyanya mu vivo kuburitswa kwemishonga nguva, ichigonesa yakagadziridzwa dosing frequency regulation, nekudaro ichiwedzera kutevedzera kurapwa kwemurwere.
Adopt 2D-LC yepamhepo desalting tekinoroji kuti uwane inonyatso zivikanwa yetsvina yakaoma. Iyi tekinoroji inogona kunyatso kugadzirisa dambudziko rekuenderana pakati pebuffer - ine mobile phases uye mass spectrometry yekuona.
Iko kubatanidzwa kweDhizaini Yezviedzo (DoE), otomatiki kuongorora, uye statistical modhi tekinoroji inosimudzira zvakanyanya yekuongorora nzira yekuvandudza kushanda uye kusimba kwemhedzisiro.
Core Kugona
1.Product Characterization Analysis
2.Analytical Method Development uye Validation
3.Kugadzikana Kudzidza
4.Kusachena Profileing Identification
JY FISTM Kuchenesa Technology Platform
1.Inoenderera mberi Chromatography
Kuenzaniswa nebatch chromatography, inopa zvakanakira zvekudzikisa zvinonyungudutsa mashandisirwo, kugadzirwa kwepamusoro, uye kukwirira kwepamusoro.
2.High-Performance Liquid Chromatography System1.
3.Kurumidza kuparadzanisa kumhanya nekuchinjika kune akasiyana peptides
Inochengetedza peptide chimiro chekuvimbika uye bioactivity, inogadziriswa zvakare nemvura.
Zvinonyanya kushanda kupfuura lyophilization, nekukurumidza scalability kune mazinga ekugadzira maindasitiri.
Recrystallization inonyanya kushandiswa muLiquid-Phase Peptide Synthesis (LPPS) mazano ekuwana yakakwirira-kuchena peptides uye zvimedu panguva imwe chete ichikwirisa makristasi zvimiro, ichipa mari-inoshanda mabhenefiti.
Core Kugona
1.Product Characterization Analysis
2.Analytical Method Development uye Validation
3.Kugadzikana Kudzidza
4.Kusachena Profileing Identification
Lab uye Pilot Equipments
LAB
Fully Automated Peptide Synthesizer
20-50 L Reactors
YXPPSTM
Prep-HPLC (DAC50 - DAC150)
Mazaya echando (0.18 m2 - 0.5m2)
PILOT
3000L SPPS
500L-5000L LPPS
Prep-HPLC DAC150 - DAC 1200mm
Otomatiki Kuunganidza System
Freeze Dryers
Spray Drier
