Peptide Synthesis Technology Platforms
Peptides umi (30 - 60 amino acids), peptides lavelave (lipopeptides, glycopeptides), peptides cyclic, non-natural amino acid peptides, peptide-nucleic acids, peptide-laiti mole, peptide-proteins, peptide-radionuclides, ma isi.
Fa'asologa o le Peptide Fa'ata'oto (SPPS)
Su'e-Vaega Peptide Fa'asusu (LPPS)
Suavai-Soild Phase Peptide Synthesis (L/SPPS)
Taiala La'ititi Puipuia Vaega mo SPPS (MP-SPPS)
Fa'afaigofie le fa'agasologa e ala i le fa'aitiitia o le fa'aogaina o vaega fa'apipi'i fa'apolopolo i le taimi o le tu'ufa'atasiga; faaitiitia le tau o reagents taugata (e pei ole Fmoc/tBu); fa'alavelave fa'alavelave (e pei o le fa'ate'a vave).
E silia ma le 60 tusi talosaga na fa'auluina e le kamupani, e aofia ai fa'ailoga fa'atau i le Iuni a Europa ma le tolu i Amerika, ma ua maua le resitalaina o le puletaofia mo galuega e fa.
Peptide Suiga Fa'avae
E ala i le fa'aofiina o vaega fa'ata'ita'i (e pei o kulupu fela'ua'i, biotin, radioisotopes) i peptide, e mafai ona ausia galuega e pei o le su'esu'eina, su'esu'eina, po'o le fa'amaoniaina o le fa'amoemoe.
O le PEGylation e fa'amalieina ai mea tau vaila'au o peptide (fa'ata'ita'iga, fa'alautele le afa o le ola ma fa'aitiitia le immunogenicity).
Au'aunaga Fa'amaopoopo Peptide (P-Drug Conjugate)
E tolu-elemene fausaga o le faiga o togafitiga faʻatatau:
Peptide Fua'i: E pipii fa'apitoa i fa'ama'i/antigens i luga o sela mama'i (e pei o sela o le kanesa);
Feso'ota'iga: Fa'apipi'i le peptide ma le vaila'au, fa'atonutonu le tu'uina atu o vaila'au (mamanu e mafai ona fa'amama/e le mafai ona fa'amama);
Totogi Fualaau Fa'asaina: Tu'u atu cytotoxins po'o vaega fa'afoma'i (e pei o vaila'au fa'ama'i, radionuclides).
Peptide Formation Technology Platforms
Fualaau Fualaau Fa'atonu: Fa'aaogaina o tekonolosi fa'aola e pei o liposomes, polymeric micelles, ma nanoparticles.
Ole faiga fou ole tu'uina atu o vaila'au e fa'aumi tele le umi ole tu'uina atu o vaila'au i vivo, e mafai ai ona fa'atumauina le fa'atonuina ole fa'atulafonoina ole taimi ole tui, fa'apea ona fa'aleleia atili ai le usita'i ole ma'i.
Fa'aaoga le 2D-LC i luga ole laiga fa'agata fa'atekonolosi e maua ai le fa'amaonia lelei o mea leaga lavelave. O lenei tekinolosi e mafai ona foia lelei le faʻafitauli o fesoʻotaʻiga i le va o le paʻu - o loʻo i ai vaega feaveaʻi ma le suʻesuʻeina o spectrometry.
O le tu'ufa'atasia o le Design of Experiments (DoE), su'esu'ega fa'apitoa, ma fa'atekonolosi fa'ata'ita'iga fa'afuainumera e matua fa'aleleia atili ai le lelei o le atina'eina o metotia su'esu'e ma le malosi o le i'uga.
Avanoa Autu
1. Su'esu'ega Fa'amatalaga o Oloa
2.Analytical Method Development and Validation
3. Suesuega Mausali
4. Fa'ailoa Fa'amatalaga Fa'aleaga
JY FISTM Purification Technology Platform
1. Fa'aauau Chromatography
Pe a faatusatusa i le chromatography batch, e ofoina atu le lelei o le faʻaitiitia o le solvent taumafaina, maualuga le gaosiga lelei, ma le maualuga scalability.
2. High-Performance Liquid Chromatography System1.
3.Saosaoa tuueseeseina vave ma fetuutuunai i peptides eseese
Fa'atumauina le fa'atonuga o le peptide ma le bioactivity, faigofie ona toe fa'afo'i i le vai.
E sili atu le lelei nai lo le lyophilization, faʻatasi ai ma le faʻavavevave faʻateleina i tulaga gaosiga o fale gaosi oloa.
O le toe fa'a'ele'ele o lo'o fa'aaoga muamua ile Liquid-Phase Peptide Synthesis (LPPS) ta'iala e maua mai ai peptide mama ma vaevaega a'o fa'apena fa'atasi le fa'aogaina o fausaga tioata, e ofoina atu fa'amanuiaga taugofie.
Avanoa Autu
1. Su'esu'ega Fa'amatalaga o Oloa
2.Analytical Method Development and Validation
3. Suesuega Mausali
4. Fa'ailoa Fa'amatalaga Fa'aleaga
Falesu'esu'e ma Meafaigaluega Pailate
LAB
Peptide Synthesizer atoatoa otometi
20-50 L Reactors
YXPPSTM
Saunia-HPLC（DAC50 – DAC150）
Mea Fa'a'aisa（0.18m2 – 0.5m2）
pailate
3000L SPPS
500L-5000L LPPS
Sauniuni-HPLC DAC150 - DAC 1200mm
Faiga otometi Aoina
Mea Fa'a'aisa
Sausau mago
