Peptide Synthesis Technology Platforms
Ma peptides aatali (30 - 60 amino acid), ma peptides ovuta (lipopeptides, glycopeptides), ma cyclic peptides, ma peptide omwe si achilengedwe amino acid, ma peptide-nucleic acid, mamolekyu ang'onoang'ono a peptide, ma peptide-mapuloteni, ma peptide-radionuclides, etc.
Solid-Phase Peptide Synthesis(SPPS)
Liquid-Phase Peptide Synthesis (LPPS)
Liquid-Soild Phase Peptide Synthesis (L/SPPS)
Minimum Protecting Group Strategy for SPPS (MP-SPPS)
Kufewetsa ndondomekoyi pochepetsa kugwiritsa ntchito magulu oteteza orthogonal panthawi ya kaphatikizidwe; kuchepetsa mtengo wa reagents okwera mtengo (monga Fmoc/tBu); kuletsa zochitika zam'mbali (monga kutetezedwa msanga).
Kampaniyo yapereka ma fomu opitilira 60, kuphatikiza zilembo zinayi ku European Union ndi zitatu ku United States, ndipo yalembetsa zolembetsa pazolemba zinayi.
Peptide Kusintha Mapulatifomu
Poyambitsa magulu a tracer (monga magulu a fulorosenti, biotin, radioisotopes) mu ma peptides, ntchito monga kutsata, kuzindikira, kapena kutsimikizira kutsata zitha kukwaniritsidwa.
PEGylation imakulitsa mphamvu ya pharmacokinetic ya peptides (mwachitsanzo, kukulitsa theka la moyo ndikuchepetsa chitetezo chamthupi).
Peptide Conjugation Services (P-Drug Conjugate)
Zomangamanga zazinthu zitatu za dongosolo lothandizira lothandizira:
Peptide Yoyang'ana: Makamaka imamangiriza ku zolandilira / ma antigen pamwamba pa maselo odwala (monga maselo a khansa);
Linker: Kumangirira peptide ndi mankhwala, kuwongolera kutulutsidwa kwa mankhwala (mapangidwe ong'ambika / osang'ambika);
Malipiro a Mankhwala: Amapereka ma cytotoxins kapena zigawo zochizira (monga chemotherapeutic mankhwala, radionuclides).
Peptide Formulation Technology Platforms
Kugwiritsa Ntchito Mankhwala Osokoneza Bongo: Kugwiritsa ntchito matekinoloje apamwamba operekera monga liposomes, polymeric micelles, ndi nanoparticles.
Njira yatsopano yoperekera mankhwala imatalikitsa nthawi yotulutsa mankhwala mu vivo, zomwe zimapangitsa kuti pakhale kuwongolera pafupipafupi kwa dosing, potero kumathandizira kutsata kwamankhwala kwa odwala.
Adopt 2D-LC ukadaulo wapaintaneti wa desalting kuti mukwaniritse kuzindikira zonyansa zovuta. Ukadaulo uwu utha kuthana bwino ndi vuto lolumikizana pakati pa buffer - yokhala ndi magawo am'manja ndi kuzindikira kwa ma spectrometry.
Kuphatikizika kwa Design of Experiments (DoE), kuyang'ana pawokha, ndi matekinoloje owerengera ziwerengero kumathandizira kwambiri pakukulitsa njira zowunikira komanso kulimba kwa zotsatira zake.
Maluso a Core
1.Kusanthula kwa Makhalidwe a Mankhwala
2.Analytical Method Development ndi Kutsimikizira
3.Kukhazikika kwa Phunziro
4.Kuzindikiritsa Mbiri Yonyansa
JY FISTM Purification Technology Platform
1.Chromatography yopitilira
Poyerekeza ndi batch chromatography, imapereka ubwino wogwiritsa ntchito zosungunulira zochepa, kupanga bwino kwambiri, komanso scalability yapamwamba.
2.High-Performance Liquid Chromatography System1.
3.Kuthamanga kwapatukana kwachangu ndi kusinthika kwa ma peptide osiyanasiyana
Imasunga umphumphu wa peptide ndi bioactivity, yokonzedwanso mosavuta ndi madzi.
Ndiwothandiza kwambiri kuposa lyophilization, ndi scalability mwachangu kumagulu opanga mafakitale.
Recrystallization imagwiritsidwa ntchito makamaka mu njira za Liquid-Phase Peptide Synthesis (LPPS) kuti apeze ma peptides ndi tizidutswa tambirimbiri kwinaku akukhathamiritsa nyumba zamakristalo, zomwe zimapereka zopindulitsa zotsika mtengo.
Maluso a Core
1.Kusanthula kwa Makhalidwe a Mankhwala
2.Analytical Method Development ndi Kutsimikizira
3.Kukhazikika kwa Phunziro
4.Kuzindikiritsa Mbiri Yonyansa
Zida za Lab ndi Pilot
LAB
Fully Automated Peptide Synthesizer
20-50 L Zopangira
Mtengo wa YXPPSTM
Prep-HPLC (DAC50 - DAC150)
Zowumitsa Zozizira (0.18 m2 - 0.5m2)
WOYAMBIRA
3000L SPPS
500L-5000L LPPS
Prep-HPLC DAC150 - DAC 1200mm
Makina Otolera Otolera
Zowumitsa Zozizira
Spray Drier
