TECHNOLOGY PLATFORMS

Ngwa teknụzụ Peptide Synthesis

Ihe mgbagwoju anya Peptides na Peptidomimetic Chemical Synthesis

Long peptides (30-60 amino acids), mgbagwoju peptides (lipopeptides, glycopeptides), cyclic peptides, na-abụghị eke amino acid peptides, peptide-nucleic acids, peptide-obere ụmụ irighiri ihe, peptide-protein, peptide-radionuclides, wdg.

Ngwa teknụzụ Peptide Synthesis

Synthesis Peptide siri ike (SPPS)
Ngwakọta Peptide nke Liquid-phase (LPPS)
Ngwakọta Peptide nke Mmiri-Akụkụ (L/SPPS)
Atụmatụ otu nchekwa kacha nta maka SPPS (MP-SPPS)
Mee ka usoro ahụ dị mfe site n'ibelata iji otu nchebe orthogonal n'oge njikọ; belata ọnụ ahịa reagents dị oke ọnụ (dị ka Fmoc/tBu); na-egbochi mmeghachi omume akụkụ (dị ka nchebe akaghi aka).

Ngwakọ-Nhazi Usoro (HPPS)

Ụlọ ọrụ ahụ etinyela ihe karịrị ngwa ụghalaahịa 60, gụnyere ụghalaahịa anọ na European Union na atọ na United States, wee nweta ndebanye aha nwebisiinka maka ọrụ anọ.

Platform Mgbanwe Peptide

Inye aha aha

Site na iwebata otu tracer (dị ka otu fluorescent, biotin, radioisotopes) n'ime peptides, enwere ike nweta ọrụ dị ka nsochi, nchọpụta, ma ọ bụ nleba anya nyocha.

PEGylated Peptides

PEGylation na-ebuli akụrụngwa pharmacokinetic nke peptides (dịka ọmụmaatụ, ịgbatị ọkara ndụ yana ibelata immunogenicity).

Nkà na ụzụ njikọ

Ọrụ Njikọta Peptide (P-Drug Conjugate)

Ihe owuwu atọ nke usoro ọgwụgwọ ezubere iche:

Peptide ezubere iche: Na-ejikọta ya na ndị na-anabata / antigens n'elu mkpụrụ ndụ ọrịa (dị ka mkpụrụ ndụ kansa);

Linker: Akwado peptide na ọgwụ ahụ, na-achịkwa ntọhapụ ọgwụ (ihe a na-emegharị emegharị / enweghị ike ime);

Ịkwụ ụgwọ ọgwụ: Na-ebuga cytotoxins ma ọ bụ ihe ọgwụgwọ (dịka ọgwụ chemotherapeutic, radionuclides).

Platform Technology Formulation Peptide

Usoro nnyefe ọnụ

Sistemụ Nkwanye ọgwụ: Iji teknụzụ nnyefe dị elu dị ka liposomes, miceles polymeric, na nanoparticles.

Teknụzụ ntọhapụ na-adịgide ogologo oge

Usoro mbufe ọgwụ ọhụrụ na-agbatịkwu ogologo oge ntọhapụ ọgwụ vivo, na-eme ka usoro usoro ọgwụgwọ kachasị mma, si otú a na-eme ka nrube isi na ọgwụgwọ ndị ọrịa.

Chromatography multidimensional

Nabata teknụzụ ịsachapụ ihe n'ịntanetị 2D-LC iji nweta njirimara dị mgbagwoju anya nke adịghị ọcha. Nkà na ụzụ a nwere ike dozie nsogbu ndakọrịta n'etiti ihe nchekwa - nwere usoro mkpanaka yana nchọpụta spectrometry mass.

FUSION®(Sistemụ nyocha nke ọgụgụ isi)

Mwekota nke Design of Experiments (DoE), nyocha akpaaka, na teknụzụ ịdepụta ọnụ ọgụgụ na-eme ka usoro nyocha dị mma mmepe mmepe na nsonaazụ siri ike.

Platform mmepe nyocha

Ike isi
1.Product Njirimara Analysis
2.Analytical Method Development and Validation
3.Stability Ọmụmụ
4.Impurity Profiling Identification

JY FISTM Nkà na ụzụ Nkachacha Ọcha

Teknụzụ nkewa/nhicha

1.Chromatography na-aga n'ihu
Tụnyere ogbe chromatography, ọ na-enye uru nke obere ihe mgbaze oriri, elu mmepụta arụmọrụ, na elu scalability.
2.High-Performance Liquid Chromatography System1.
3.Ọsọ nkewa ngwa ngwa yana mgbanwe na peptides dị iche iche

Mmepe usoro Lyophilization

Na-ejigide iguzosi ike n'ezi ihe nhazi peptide na bioactivity, ejiri mmiri megharịa ngwa ngwa.

Mmepe usoro ịgbasa

Na-arụ ọrụ nke ọma karịa lyophilization, yana ngwa ngwa scalability na ọkwa mmepụta mmepụta ihe.

Recrystalization

A na-eji recrystallization arụ ọrụ na usoro Liquid-Phase Peptide Synthesis (LPPS) iji nweta peptides na iberibe dị ọcha ma na-ebuli ihe owuwu kristal n'otu oge, na-enye uru bara uru.

Platform mmepe nyocha

Ike isi
1.Product Njirimara Analysis
2.Analytical Method Development and Validation
3.Stability Ọmụmụ
4.Impurity Profiling Identification