Peptide Synthesis Technology Platforms
Ntev peptides (30 - 60 amino acids), complex peptides (lipopeptides, glycopeptides), cyclic peptides, non - natural amino acid peptides, peptide-nucleic acids, peptide-me me molecules, peptide-proteins, peptide-radionuclides, thiab lwm yam.
Solid-Phase Peptide Synthesis (SPPS)
Liquid-Phase Peptide Synthesis (LPPS)
Liquid-Soild Phase Peptide Synthesis (L/SPPS)
Yam tsawg kawg nkaus tiv thaiv pab pawg tswv yim rau SPPS (MP-SPPS)
Ua kom yooj yim ntawm cov txheej txheem los ntawm kev txo qis kev siv cov pab pawg tiv thaiv orthogonal thaum lub sijhawm sib xyaw; txo tus nqi ntawm cov tshuaj reagents kim (xws li Fmoc/tBu); inhibit kev cuam tshuam sab (xws li kev tiv thaiv ntxov ntxov).
Lub tuam txhab tau ua tiav 60 daim ntawv thov kev lag luam, suav nrog plaub lub cim lag luam hauv European Union thiab peb lub tebchaws hauv Tebchaws Meskas, thiab tau txais cov ntawv sau npe rau plaub txoj haujlwm.
Peptide Hloov Kho Platforms
Los ntawm kev qhia cov pab pawg tracer (xws li pab pawg fluorescent, biotin, radioisotopes) rau hauv peptides, kev ua haujlwm xws li kev taug qab, nrhiav pom, lossis kev txheeb xyuas qhov tseeb tuaj yeem ua tiav.
PEGylation optimizes cov tshuaj pharmacokinetic ntawm peptides (piv txwv li, ncua ib nrab-lub neej thiab txo cov immunogenicity).
Peptide Conjugation Services (P-Drug Conjugate)
Peb lub ntsiab lus architecture ntawm lub hom phiaj kho system:
Targeting Peptide: Tshwj xeeb khi rau receptors / antigens nyob rau saum npoo ntawm cov kab mob (xws li mob qog noj ntshav);
Linker: Txuas cov peptide thiab cov tshuaj, tswj cov tshuaj tso tawm (cleavable / non-cleavable design);
Kev Siv Tshuaj: xa cov cytotoxins lossis cov tshuaj kho mob (xws li cov tshuaj kws khomob, radionuclides).
Peptide Formulation Technology Platforms
Drug Loading Systems: Siv cov thev naus laus zis xa khoom xws li liposomes, polymeric micelles, thiab nanoparticles.
Lub tshuab xa tshuaj tshiab ua kom ntev ntev hauv vivo cov tshuaj tso tawm lub sijhawm, ua kom muaj kev tswj hwm kev siv tshuaj ntau zaus, yog li txhim kho kev kho tus neeg mob.
Txais 2D-LC online desalting thev naus laus zis kom ua tiav kev txheeb xyuas qhov nyuaj ntawm impurities. Cov thev naus laus zis no tuaj yeem daws qhov teeb meem kev sib raug zoo ntawm qhov tsis-muaj cov theem ntawm cov xov tooj ntawm tes thiab kev tshawb nrhiav huab hwm coj loj.
Kev sib koom ua ke ntawm Kev Tsim Kho Kev Tshawb Fawb (DoE), kev tshuaj ntsuam xyuas tsis siv neeg, thiab cov qauv kev txheeb xyuas cov thev naus laus zis ua rau muaj txiaj ntsig zoo txhim kho txoj kev tshuaj ntsuam xyuas kev txhim kho kev ua tau zoo thiab kev ua tau zoo.
Core peev xwm
1.Product Characterization Analysis
2.Txoj kev tsom xam kev txhim kho thiab kev siv tau
3. Kev tshawb fawb txog kev ruaj ntseg
4.Impurity Profiling Qhia
JY FISTM Purification Technology Platform
1.Nruam Chromatography
Piv rau batch chromatography, nws muaj qhov zoo ntawm kev siv cov kuab tshuaj qis dua, kev ua haujlwm ntau dua, thiab kev ua kom zoo dua.
2.High-Performance Liquid Chromatography System1.
3.Kev sib cais ceev ceev nrog adaptability rau ntau yam peptides
Khaws peptide kev ncaj ncees thiab bioactivity, yooj yim reconstituted nrog dej.
Muaj txiaj ntsig zoo dua li lyophilization, nrog kev ua kom nrawm nrawm rau qib kev lag luam.
Recrystallization feem ntau yog ua haujlwm nyob rau hauv Liquid-Phase Peptide Synthesis (LPPS) cov tswv yim kom tau txais cov peptides siab thiab cov khoom tawg yooj yim thaum ua kom zoo dua cov qauv siv lead ua, muab cov txiaj ntsig zoo.
Core peev xwm
1.Product Characterization Analysis
2.Txoj kev tsom xam kev txhim kho thiab kev siv tau
3. Kev tshawb fawb txog kev ruaj ntseg
4.Impurity Profiling Qhia
Lab thiab Pilot Equipments
LAB
Puv Automated Peptide Synthesizer
20-50L Reactors
YXPPSTM
Prep-HPLC (DAC50 - DAC150)
Freeze Dryers (0.18 m2 - 0.5m2)
PILOT
3000L SPPS
500L-5000L LPPS
Prep-HPLC DAC150 - DAC 1200mm
Tsis Siv Neeg Sau System
Lub Tshuab ziab khaub ncaws
Txau Drier
