Platform Technology Platform Synthesis Peptide
Dogon peptides (30-60 amino acids), hadaddun peptides (lipopeptides, glycopeptides), peptides cyclic, peptides na halitta amino acid, peptide-nucleic acid, peptide-kananan kwayoyin, peptide-proteins, peptide-radionuclides, da dai sauransu.
Ƙaƙƙarfan Tsarin Peptide Synthesis (SPPS)
Liquid-Phase Peptide Synthesis (LPPS)
Ruwan-Ƙasa Phase Peptide Synthesis (L/SPPS)
Dabarun Ƙungiya mafi ƙanƙanta don SPPS (MP-SPPS)
Sauƙaƙe tsari ta hanyar rage amfani da ƙungiyoyin kariyar orthogonal yayin haɗuwa; rage farashin reagents masu tsada (kamar Fmoc/tBu); hana halayen gefe (kamar rashin kariya da wuri).
Kamfanin ya shigar da aikace-aikacen alamar kasuwanci sama da 60, gami da alamun kasuwanci huɗu a cikin Tarayyar Turai da uku a Amurka, kuma ya sami rajistar haƙƙin mallaka na ayyuka huɗu.
Platform Gyaran Peptide
Ta hanyar gabatar da ƙungiyoyi masu ganowa (kamar ƙungiyoyi masu kyalli, biotin, radioisotopes) cikin peptides, ayyuka kamar sa ido, ganowa, ko tabbatar da niyya za a iya cimma.
PEGylation yana haɓaka kaddarorin pharmacokinetic na peptides (misali, tsawaita rabin rayuwa da rage rigakafi).
Ayyukan haɗin gwiwar Peptide (P-Drug Conjugate)
Gine-gine na abubuwa uku na tsarin jiyya da aka yi niyya:
Peptide mai niyya: Musamman yana ɗaure ga masu karɓa / antigens akan saman ƙwayoyin cuta (kamar ƙwayoyin cutar kansa);
Linker: Gada peptide da miyagun ƙwayoyi, daidaita sakin miyagun ƙwayoyi (ƙirar da za a iya cirewa / ba za a iya cirewa);
Adadin Magunguna: Yana ba da cytotoxins ko abubuwan warkewa (kamar magungunan chemotherapeutic, radionuclides).
Platform Technology Formulation Peptide
Tsarukan Load da Magunguna: Yin amfani da fasahar isar da ci gaba kamar liposomes, micelles polymeric, da nanoparticles.
Sabbin tsarin isar da magunguna yana tsawaitawa sosai a cikin tsawon lokacin sakin magani, yana ba da damar ingantacciyar ka'idojin mitar magunguna, don haka haɓaka riko da jiyya na haƙuri.
Ɗauki fasahar lalata 2D-LC akan layi don cimma ingantaccen ganewar ƙazanta masu rikitarwa. Wannan fasaha na iya magance matsalar daidaitawa daidai gwargwado tsakanin majigi - mai ɗauke da matakan wayar hannu da gano ma'auni.
Haɗin Tsarin Gwaje-gwaje (DoE), dubawa ta atomatik, da fasahar ƙididdiga na ƙididdiga suna haɓaka ingantaccen hanyoyin haɓaka hanyoyin nazari da ƙarfin sakamako.
Mahimman Ƙarfi
1.Product Halayen Analysis
2.Analytical Hanyar Ci gaba da Tabbatarwa
3.Nazarin Kwanciyar Hankali
4.Tsarin Fahimtar Rashin Tsabta
Dandalin Fasahar Tsarkakewar JY FISTM
1.Chromatography mai ci gaba
Idan aka kwatanta da batch chromatography, yana ba da fa'idodi na ƙarancin amfani da sauran ƙarfi, ingantaccen samarwa, da haɓaka mafi girma.
2.Tsarin Chromatography Liquid Mai Haɓakawa1.
3.Saurin rabuwa da sauri tare da daidaitawa zuwa nau'ikan peptides
Yana kiyaye amincin tsarin peptide da bioactivity, cikin sauƙin sake ginawa da ruwa.
Mahimmanci mafi inganci fiye da lyophilization, tare da saurin haɓakawa zuwa matakan samar da masana'antu.
Ana amfani da recrystallization da farko a cikin dabarun Liquid-Phase Peptide Synthesis (LPPS) don samun tsaftataccen peptides da gutsuttsura yayin da ake haɓaka tsarin crystal a lokaci guda, yana ba da fa'idodi masu tsada.
Mahimman Ƙarfi
1.Product Halayen Analysis
2.Analytical Hanyar Ci gaba da Tabbatarwa
3.Nazarin Kwanciyar Hankali
4.Tsarin Fahimtar Rashin Tsabta
Lab da Kayan Aikin Jirgin Sama
LAB
Peptide Synthesizer Mai Cikakkiyar Aiki
20-50 L Reactor
YXPPSTM
Prep-HPLC (DAC50-DAC150)
Daskare Dryers (0.18m2 - 0.5m2)
PILOT
3000L SPPS
Saukewa: 500L-5000L
Prep-HPLC DAC150 - DAC 1200mm
Tsarin Tarin atomatik
Daskare Dryers
Fesa Drier
